Diphenhydramine, by contrast, caused impairment on all these measures. Loratadine e. The study found that loratadine fared the same as a placebo with regards to side effects while patients taking diphenhydramine reported fatigue, sleepiness, and low motivation, and demonstrated poorer cognitive performance [5]. Fexofenadine e. In one trial of 42 people, a single dose of diphenhydramine significantly slowed response time, increased omission errors, and increased drowsiness compared with placebo [14].
Fexofenadine did not cause any significant changes. Another trial in 42 aviation personnel found that a single fexofenadine treatment resulted in faster reaction time, fewer omission and commission errors, and better delayed recall accuracy compared to diphenhydramine treatment [15]. Cetirizine e. Clinical evidence confirmed that it is more likely to cause sedation than other newer medications options [11].
It does, however, have the fastest onset of action among the newer antihistamines. Another speaker at the Sanofi-Aventis-sponsored symposium, Dr. Ian Hindmarch, took a harder-line stance. The often-cited distinction between first- and second-generation antihistamines is mostly marketing hype. Hindmarch, professor emeritus of psychopharmacology at the University of Surrey England. Women are either pregnant or not pregnant. There is no such thing as being a little bit pregnant.
Physicians are generally told that second-generation antihistamines are causing less cognitive impairment than the first-generation agents, but some of the newer medications may produce impairment if used at or above the recommended doses. Overall, second-generation, nonsedating antihistamines have a lower tendency to cross the blood-brain barrier and thus cause fewer central nervous system side effects than their first-generation counterparts.
However, researchers have cautioned that there are differences among the second-generation agents in their effects on cognitive function.
You can find someone on IFM. You are also welcome to contact our office to work with one of our team. Necessary cookies are absolutely essential for the website to function properly.
This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information. Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies.
It is mandatory to procure user consent prior to running these cookies on your website. Skip to content. SoundCloud page opens in new window Pinterest page opens in new window YouTube page opens in new window Instagram page opens in new window Twitter page opens in new window Facebook page opens in new window.
Acetylcholine is involved in learning and memory, as well as muscle contraction. You should only discontinue a prescribed medication under physician approval and supervision.
0コメント